If you are an ISP, or an organization with a large number of users, you will want to turn off LoadAndKeep so that you don't over-tax your server's memory.
In the SpamSleuthServer.INI, set:
[General]
LoadAndKeep=0
This option will on-demand load the configuration on an as-needed basis. In this configuration, you can have a large number of users. We recommend that you set this option if you have over 500 users, or if you have over 100 users that are using the Bayesian Analyzer.